Synthesis and biological evaluation of bengacarboline derivatives.
Bioorg Med Chem Lett
; 18(3): 1212-6, 2008 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-18083028
Novel derivatives of the marine alkaloid bengacarboline have been synthesized. The seco derivatives 11 and 12 were evaluated for topoisomerase inhibition, DNA damages, cytotoxicity and cell cycle perturbation. The two synthetic analogs are more potent cytotoxic agents than bengacarboline and they both induce an accumulation of cells in the S phase of DNA synthesis. They do not function as topoisomerase inhibitors but trigger DNA damages in cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbolinas
/
Apoptosis
/
Alcaloides
/
Inhibidores de Topoisomerasa II
/
Antineoplásicos Fitogénicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido