[The renal nerve and cardiovascular responses to renal receptor stimulation with veratrine in dogs].
Nihon Jinzo Gakkai Shi
; 33(11): 1055-61, 1991 Nov.
Article
en Ja
| MEDLINE
| ID: mdl-1808357
ABSTRACT
Renal nerve and cardiovascular effects of intrarenal veratrine (Ver) were investigated using the cross-perfused kidney preparations of anesthetized dogs. Ver (1 and 3 micrograms/kg), injected as a bolus, elicited increases in arterial blood pressure (ABP), heart rate (HR) and renal efferent nerve activity (RENA). Ganglion blockade, hexametonium (2 mg/kg) markedly diminished increases in ABP, HR and RENA induced by Ver. In a separate group of animals, significant increases in renal afferent nerve activity (RANA) occurred after Ver administration. It is concluded that selective intrarenal Ver activates renal nerve afferents, and these results in cardiovascular changes are consistent with efferent sympathetic activation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Receptoras Sensoriales
/
Sistema Nervioso Simpático
/
Presión Sanguínea
/
Veratrina
/
Frecuencia Cardíaca
/
Riñón
Límite:
Animals
Idioma:
Ja
Revista:
Nihon Jinzo Gakkai Shi
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP