Phloroglucinols with prooxidant activity from Garcinia subelliptica.
J Nat Prod
; 71(2): 246-50, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18166016
ABSTRACT
A new phloroglucinol, garcinielliptone HF ( 1), possessing an unprecedented skeleton, and the tautomeric pair of garcinielliptone FC ( 2/ 2a) were isolated from the heartwood and pericarp of Garcinia subelliptica, respectively. Their structures, including relative configurations, were elucidated by means of spectroscopic methods. The ability of compounds 1 and 2/ 2a to induce DNA-cleavage activity was examined using supercoiled plasmid pBR322 DNA. In the presence of Cu(II), compounds 1 and 2/ 2a caused significant breakage of pBR322 DNA. The involvement of H2O2 and O2 (*-), and H2O2, O2 (*-), and OH (*) in 1- and 2/ 2a-mediated scission, respectively, was established by inhibition or no protection of DNA breakage by various oxygen radical scavengers. Thus, in the presence Cu(II), 1 and 2/ 2a may show a prooxidant effect on DNA and induce cell death.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Floroglucinol
/
Plantas Medicinales
/
Benzofenonas
/
Oxidantes
/
Garcinia
Idioma:
En
Revista:
J Nat Prod
Año:
2008
Tipo del documento:
Article
País de afiliación:
China