[Prostatic hypertrophy and prostate cancer].
Nihon Rinsho
; 66(1): 182-5, 2008 Jan.
Article
en Ja
| MEDLINE
| ID: mdl-18186262
ABSTRACT
Synthetic steroidal hormone has been used as the antiandrogens for prostatic hypertrophy, and prostate cancer. In prostate cancer, antiandrogens are defined as substances which prevent androgens from expressing their activity at target sites and divided into steroidal and nonsteroidal antiandrogens. Steroidal antiandrogens have negative feedback inhibition of the hypothalamus, resulting the low plasma concentration of testosterone. Nonsteroidal antiandrogens have antiandrogenic effect in both hypothalamus and target tissues, negative feedback is inhibited and the plasma concentration of testosterone is high. Antiandrogen is generally used with LH-RHa for the neoadjuvant or adjuvant hormonal therapy of surgery and irradiation which is named maximam androgen blockade.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Inhibidores de la Angiogénesis
Límite:
Humans
/
Male
Idioma:
Ja
Revista:
Nihon Rinsho
Año:
2008
Tipo del documento:
Article