19-Nordeoxycorticosterone synthesis by rat kidney inner medullary collecting duct cells.
Steroids
; 56(12): 578-80, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1819867
ABSTRACT
19-Nordeoxycorticosterone (19-nor-Doc), a potent mineralocorticoid, was found to be synthesized by the isolated rat kidney perfused by an adrenal precursor (19-oxo-Doc). To determine if this bioconversion is a function of renal tubular cells, various adrenal precursors of 19-nor-Doc were added separately to rat kidney inner medullary collecting duct cells culture media at a concentration of 10 nM. While 4.6% +/- 1.0% of 19-oxo-Doc (n = 3) and 14.4% +/- 1.4% of 19-oic-Doc (n = 3) were converted to 19-nor-Doc after 24 hours of incubation, Doc, and 19-OH-Doc were not converted. This represents further evidence that Doc has to be metabolized to 19-oxo-Doc or 19-oic-Doc (19-carboxy-Doc) before it can be converted by the kidney inner medullary collecting duct cells to 19-nor-Doc.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desoxicorticosterona
/
Médula Renal
/
Túbulos Renales Colectores
Límite:
Animals
Idioma:
En
Revista:
Steroids
Año:
1991
Tipo del documento:
Article