Pharmacokinetic profiles of prazepam and 14C-prazepam in rat.

Dios-Vieitez, M C; Renedo, M J; Fos, D

Dios-Vieitez, M C; Renedo, M J; Fos, D.

Afiliación

Dios-Vieitez MC; Departamento de Farmacia y Technologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Spain.

Eur J Drug Metab Pharmacokinet ; Spec No 3: 3-8, 1991.

Article en En | MEDLINE | ID: mdl-1820896

ABSTRACT

ABSTRACT

Pharmacokinetics of Prazepam and 14C-Prazepam were studied in rat. Prazepam was measured in blood and plasma by a gas-liquid chromatography assay with an electron capture detector. Its major metabolite, Desmethyldiazepam, was also determined in blood in the same way. Total radioactivity was measured in plasma by scintillation spectrometry. Pharmacokinetic analysis were carried out by two ways; according to compartmental pharmacokinetic models and by statistic moments.

Asunto(s)

Prazepam/farmacocinética; Animales; Cromatografía de Gases; Semivida; Inyecciones Intravenosas; Masculino; Nordazepam/sangre; Prazepam/sangre; Ratas; Ratas Endogámicas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prazepam Límite: Animals Idioma: En Revista: Eur J Drug Metab Pharmacokinet Año: 1991 Tipo del documento: Article País de afiliación: España

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