Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
Arch Dis Child
; 93(2): 151-3, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18208989
ABSTRACT
We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase gamma gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Ácido Valproico
/
Fallo Hepático Agudo
/
ADN Polimerasa Dirigida por ADN
/
Mutación
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
Arch Dis Child
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido