Analysis of large-scale sequencing of small RNAs.
Pac Symp Biocomput
; : 126-36, 2008.
Article
en En
| MEDLINE
| ID: mdl-18229681
ABSTRACT
The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs (piRNAs). piRNAs are longer than miRNAs, close to 30 nucleotides in length, involved in various functions, such as the suppression of transposons in germline. Since a large number of them (many tens of thousands) are generated from a wide range of positions in the genome, large-scale sequencing is the only way to study them. The key to understanding their genesis and biological roles is efficient analysis, which is complicated by the large volumes of sequence data. Taking account of the underlying biology is also important. We describe here novel analyses techniques and tools applied to small RNAs from germ cells in D. melanogaster, that allowed us to infer mechanism and biological function.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN
/
Análisis de Secuencia de ARN
Límite:
Animals
Idioma:
En
Revista:
Pac Symp Biocomput
Asunto de la revista:
BIOTECNOLOGIA
/
INFORMATICA MEDICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos