Annexin A1 in the brain--undiscovered roles?
Trends Pharmacol Sci
; 29(3): 135-42, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-18262660
ABSTRACT
Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Anexina A1
/
Enfermedades del Sistema Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido