Evaluation of the developmental toxicity of diallyl phthalate administered orally to rats.
Food Chem Toxicol
; 46(6): 2150-6, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18375032
ABSTRACT
The objective of this study was to evaluate the developmental toxic potential of diallyl phthalate (DAP) in rats. Pregnant Sprague-Dawley rats were given DAP at doses of 0 (olive oil), 100, 150, 200, and 250mg/kg/day, by gavage (5ml/kg), on Gestational Days (GD) 6 through 20. Gross examination at necropsy revealed liver lesions in dams given 150mg/kg/day or higher doses. In addition, maternal weight gain and food consumption were significantly reduced at 200 and 250mg/kg/day. There was no significant increase in the incidence of resorptions, or malformations, at any dose. Fetal body weight was significantly reduced at 200 and 250mg/kg/day. There was a significant increase in the incidence of fetuses with skeletal variations at 250mg/kg/day. Retarded ossification of certain bones (i.e. forelimb and hindlimb phalanges, metatarsals, and caudal vertebrae) was also observed. There was no sign of developmental toxicity at 100 and 150mg/kg/day. Thus, DAP caused fetal toxicity at doses which also produced maternal effects, but no embryolethality or teratogenicity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Ftálicos
/
Teratógenos
/
Anomalías Inducidas por Medicamentos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia