Optical tweezers for single cells.
J R Soc Interface
; 5(24): 671-90, 2008 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-18381254
ABSTRACT
Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT for nanomechanical characterization of various biological cells are discussed in terms of both their theoretical and experimental advancements. The future trends of employing OT in single cells, especially in stem cell delivery, tissue engineering and regenerative medicine, are prospected. More importantly, current limitations and future challenges of OT for these new paradigms are also highlighted in this review.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Separación Celular
/
Nanotecnología
/
Técnicas Analíticas Microfluídicas
/
Pinzas Ópticas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J R Soc Interface
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido