[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I]. / Drohende Cumarinnekrose bei einer 24-jährigen Patientin mit stattgehabter Beinvenenthrombose.

Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.