Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole.
World J Gastroenterol
; 14(15): 2406-10, 2008 Apr 21.
Article
en En
| MEDLINE
| ID: mdl-18416470
ABSTRACT
AIM:
To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg.METHODS:
Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug.RESULTS:
The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg.CONCLUSION:
In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidine than by LPZ.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Piridinas
/
2-Piridinilmetilsulfinilbencimidazoles
/
Inhibidores de la Bomba de Protones
/
Ácido Gástrico
/
Mucosa Gástrica
/
Antagonistas de los Receptores H2 de la Histamina
/
Acetamidas
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
World J Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón