Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.
Semin Cell Biol
; 2(4): 195-204, 1991 Aug.
Article
en En
| MEDLINE
| ID: mdl-1842338
ABSTRACT
The cdc2 protein kinase, first identified as a cell cycle gene required for transition into the S- and M-phases of budding and fission yeast, has been shown to act as a key component in the regulation of the eukaryotic cell cycle. The periodic activation of cdc2 kinase, which is required for entry into M-phase, is regulated by subunit association with cyclin B, the cdc25, wee1, mik1 gene products and differential phosphorylation of the cdc2 protein. Phosphorylation at Tyr 15 inhibits activation of the cdc2/cdc13 complex whereas phosphorylation of Thr 167 is required for kinase activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Schizosaccharomyces
/
Proteína Quinasa CDC2
Idioma:
En
Revista:
Semin Cell Biol
Año:
1991
Tipo del documento:
Article