Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Nat Genet
; 40(6): 713-5, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18438405
ABSTRACT
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Variación Genética
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Cromosomas Humanos Par 3
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Biomarcadores
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Colitis Ulcerosa
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Enfermedad de Crohn
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
/
Male
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Alemania