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Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia.
Zhang, Hong-Xing; Zhao, Jing-Ping; Lv, Lu-Xian; Li, Wen-Qiang; Xu, Lin; Ouyang, Xuan; Yuan, Zhi-Qing; Huang, Jin-Song.
Afiliación
  • Zhang HX; Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha 410011, China.
Neurosci Lett ; 438(1): 1-5, 2008 Jun 13.
Article en En | MEDLINE | ID: mdl-18455303
Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Linfocitos / Expresión Génica / Predisposición Genética a la Enfermedad / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2008 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Linfocitos / Expresión Génica / Predisposición Genética a la Enfermedad / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2008 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda