Other potential medical therapies: the use of antiviral agents to investigate and treat primary ciliary cirrhosis.
Clin Liver Dis
; 12(2): 445-60; xi, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18456190
ABSTRACT
A human betaretrovirus has been characterized in patients with primary biliary cirrhosis (PBC) and the related mouse mammary tumor virus linked with autoimmune biliary disease in the NOD.c3c4 mouse model. Translational studies have been performed in patients who have PBC to investigate the role of viral infection in disease. Patients treated with Combivir experienced significant improvements in hepatic biochemistry, clinical symptoms, and histology with evidence of reversal of ductopenia. Preliminary studies suggest that the NOD.c3c4 mouse model of PBC provides a good model to test safer and more potent drug regimens for future use in trials for patients who have PBC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Cirrosis Hepática Biliar
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2008
Tipo del documento:
Article