Characteristics of HCN channels and their participation in neuropathic pain.
Neurochem Res
; 33(10): 1979-89, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18461446
ABSTRACT
Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Canales de Potasio
/
Canales Catiónicos Regulados por Nucleótidos Cíclicos
Límite:
Animals
Idioma:
En
Revista:
Neurochem Res
Año:
2008
Tipo del documento:
Article