Severe attacks of familial hemiplegic migraine, childhood epilepsy and ATP1A2 mutation.
Cephalalgia
; 28(7): 774-7, 2008 Jul.
Article
en En
| MEDLINE
| ID: mdl-18498390
ABSTRACT
We studied four members of a family suffering from typical attacks of familial hemiplegic migraine (FHM) caused by a new mutation, R548C, of ATP1A2 gene in exon 12. One individual had also childhood absence epilepsy and generalized tonic-clonic seizures (GTCS). GTCS were followed by a severe attack of hemiplegic migraine at four times. Sodium valproate enabled control of both the epileptic seizures and the most severe FHM attacks. This association of FHM and epileptic seizures and their control with the same treatment suggest similar pathophysiological mechanisms.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epilepsia Tónico-Clónica
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Epilepsia Tipo Ausencia
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ATPasa Intercambiadora de Sodio-Potasio
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Mutación Missense
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Migraña con Aura
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Cephalalgia
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia