Association of E1AF mRNA expression with tumor progression and matrilysin in human rectal cancer.
Oncology
; 73(5-6): 384-8, 2007.
Article
en En
| MEDLINE
| ID: mdl-18511876
ABSTRACT
OBJECTIVE:
To examine E1AF mRNA expression and to determine whether it is correlated with tumor progression and matrilysin in human rectal cancer.METHODS:
Real-time RT-PCR was used to determine E1AF and matrilysin expression in 100 matched rectal cancers and normal tissues.RESULTS:
Among the 100 rectal cancers, 69 cases of E1AF mRNA overexpression were observed. E1AF mRNA overexpression correlated well with matrilysin. In carcinomas, E1AF mRNA overexpression correlated significantly with depth of invasion, lymph node metastasis, venous involvement and advanced pTNM stage.CONCLUSIONS:
E1AF was correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
/
ARN Mensajero
/
Proteínas Proto-Oncogénicas
/
Proteínas E1A de Adenovirus
/
Metaloproteinasa 7 de la Matriz
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oncology
Año:
2007
Tipo del documento:
Article
País de afiliación:
China