Searching for disease susceptibility variants in structured populations.
Genomics
; 93(1): 1-4, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-18519160
ABSTRACT
Data for genome-wide association studies are being collected for a myriad of phenotypes. Many of these studies do not include control samples selected to reflect ancestry similar to the case samples. At the same time "control databases" are becoming available to be utilized as a common resource. These data are often genotyped using a large-scale SNP array. Human populations exhibit complex structure that can lead to spurious associations if not properly handled. How to couple case and control databases effectively is a pressing question. We review available methods for modeling genetic ancestry based on the information gleaned from the SNP array. Methods for selecting control samples with genetic ancestry similar to the case samples are described.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Estudio de Asociación del Genoma Completo
/
Genética de Población
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos