Potential mechanisms of resistance to microtubule inhibitors.
Semin Oncol
; 35(3 Suppl 3): S22-7, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18538175
ABSTRACT
Antimitotic drugs targeting the microtubules, such as the taxanes and vinca alkaloids, are widely used in the treatment of neoplastic diseases. Development of drug resistance over time, however, limits the efficacy of these agents and poses a clinical challenge to long-term improvement of patient outcomes. Understanding the mechanism(s) of drug resistance becomes paramount to allowing for alternative, if not improved, therapeutic options that might circumvent this challenge. Vinflunine, a novel microtubule inhibitor, has shown superior preclinical antitumor activity, and displays a different pattern of resistance, compared with other agents in the vinca alkaloid class.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vinblastina
/
Resistencia a Antineoplásicos
/
Moduladores de Tubulina
/
Microtúbulos
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Semin Oncol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Australia