Your browser doesn't support javascript.
loading
Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.
Olivier, J D A; Jans, L A W; Korte-Bouws, G A H; Korte, S M; Deen, P M T; Cools, A R; Ellenbroek, B A; Blokland, A.
Afiliación
  • Olivier JD; Department of Cognitive Neuroscience: Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. j.olivier@cns.umcn.nl
Psychopharmacology (Berl) ; 200(2): 243-54, 2008 Oct.
Article en En | MEDLINE | ID: mdl-18542930
ABSTRACT
RATIONALE Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats.

OBJECTIVES:

As individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin transporter knockout (SERT(-/-)), rats marked by a lower SERT function, are more vulnerable to the effects of ATD in an object recognition task than male wildtype (SERT(+/+)) and heterozygous (SERT(+/-)) rats. MATERIALS AND

METHODS:

Twelve male SERT(+/+), SERT(+/-), and SERT(-/-) rats were treated with standard dose and low-dose ATD using a gelatine-based protein-carbohydrate mixture lacking tryptophan. In the control treatment, L -tryptophan was added to the mixture. Four hours after treatment, the rats were subjected to the object recognition task. In addition, the effects of ATD on plasma amino acid concentrations were measured, and concentrations of 5-HT and 5-HIAA were measured in the frontal cortex and hippocampus of these rats.

RESULTS:

Plasma TRP levels and central 5-HT and 5-HIAA levels were decreased in all genotypes after ATD, but effects were stronger in SERT(-/-) rats. The standard dose of ATD impaired object recognition in all genotypes. SERT(-/-) and SERT(+/-) rats were more vulnerable to low dose of ATD in the object recognition task compared to SERT(+/+) rats.

CONCLUSIONS:

These results indicate a greater sensitivity to ATD in SERT(-/-) and SERT(+/-) rats, which may be related to stronger central depletion effects in these rats.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Proteínas de Transporte de Serotonina en la Membrana Plasmática / Aminoácidos / Trastornos de la Memoria Límite: Animals Idioma: En Revista: Psychopharmacology (Berl) Año: 2008 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Proteínas de Transporte de Serotonina en la Membrana Plasmática / Aminoácidos / Trastornos de la Memoria Límite: Animals Idioma: En Revista: Psychopharmacology (Berl) Año: 2008 Tipo del documento: Article País de afiliación: Países Bajos
...