Evaluation of ISCOMATRIX and ISCOM vaccines for immunisation against Helicobacter pylori.
Vaccine
; 26(31): 3880-4, 2008 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-18547687
ABSTRACT
An important obstacle to development of an effective vaccine against Helicobacter pylori is the lack of a suitable adjuvant. This study evaluated the effectiveness of ISCOMATRIX and ISCOM vaccines at inducing protective immunity against H. pylori in mice. Immunisation with ISCOMATRIX and ISCOM vaccines resulted in a reduction in H. pylori colonisation equivalent to that induced by the gold standard cholera toxin (CT) adjuvant. Protection was induced in two mouse backgrounds, using two different bacterial antigens and following vaccine delivery via either the intranasal or subcutaneous route. This supports the potential of ISCOMATRIX and ISCOM technologies in H. pylori vaccine development.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Saponinas
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Vacunas Bacterianas
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Adyuvantes Inmunológicos
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Colesterol
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Helicobacter pylori
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Infecciones por Helicobacter
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ISCOMs
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2008
Tipo del documento:
Article
País de afiliación:
Australia