Neural and anatomical abnormalities of the gastrointestinal system resulting from contusion spinal cord injury.
Neuroscience
; 154(4): 1627-38, 2008 Jul 17.
Article
en En
| MEDLINE
| ID: mdl-18556138
ABSTRACT
Gastrointestinal (GI) abnormalities resulting from spinal cord injury (SCI) are challenging disorders that have not been examined experimentally using clinically relevant models. In this study, female Sprague-Dawley rats (n=5/groupx4 T10-T11 contusion, laminectomy, or naïve) were fasted for 24 h before being submitted to dye recovery assays (Phenol Red solution, 1.5 ml/rat; per oral) on GI emptying/transiting at 48 h or 4 weeks postinjury (p.i.). Compared with controls, SCI significantly increased dye recovery rate (DRR, determined by spectrophotometry) in the duodenum (+84.6%) and stomach (+32.6%), but decreased it in the jejunum (-64.1% and -49.5%) and ileum (-73.6% and -70.1%) at 48 h and 4 weeks p.i., respectively (P
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Enfermedades Gastrointestinales
Límite:
Animals
Idioma:
En
Revista:
Neuroscience
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos