A canine model of inherited myopia: familial aggregation of refractive error in labrador retrievers.
Invest Ophthalmol Vis Sci
; 49(11): 4784-9, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-18566472
ABSTRACT
PURPOSE:
To determine whether the distribution of naturally occurring myopia in Labrador Retrievers has a genetic component.METHODS:
Pedigree records of a large canine family were analyzed. Pure Labrador Retrievers, 1 to 8 years of age, free of ocular disease, and available for testing were studied. Refractive error was measured by cycloplegic retinoscopy in both eyes. The family included mating loops, and so an expectation maximization (EM) algorithm (multivar program, MORGAN software; University of Washington, Seattle) was used to calculate log likelihoods of refractive error with environmental and additive genetic models. The fixed effects of coat color, sex, and litter size were also tested.RESULTS:
In our sample of 116 dogs from this one family, the average spherical equivalent refraction (SER) was -0.41 D (range, -5.38 to +1.65 D, mean of both eyes, n = 116) 31% were myopic (SERCONCLUSIONS:
The distribution of refractive error within this family of Labrador Retrievers had a significant genetic component, but was also influenced by other factors (litter size, and undefined residual/environmental effects). The dog represents a unique model for the study of naturally occurring, heritable, high-prevalence, low-degree myopia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linaje
/
Refracción Ocular
/
Predisposición Genética a la Enfermedad
/
Enfermedades de los Perros
/
Miopía
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
2008
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda