Neuropeptide Y (NPY) Y2 receptors of rabbit kidney cortex are largely dimeric.
Regul Pept
; 150(1-3): 88-94, 2008 Oct 09.
Article
en En
| MEDLINE
| ID: mdl-18585408
ABSTRACT
The neuropeptide Y (NPY) Y2 receptors and the pancreatic polypeptide Y4 receptors from rabbit kidney cortex are isolated largely as approximately 180 kDa complexes constituted of one receptor dimer and one G-protein heterotrimer, similar to NPY receptors expressed in the Chinese hamster ovary (CHO) cells. As expected, kidney and CHO cell Y2 dimers are converted into monomers by increasing concentrations of a selective agonist. Prevalence of dimeric Y2 receptors in the kidney could be related to low plasma levels of Y2 agonists, and possibly also to a relatively low concentration of Gi alpha subunits.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Neuropéptido Y
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Proteínas de Unión al GTP
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Subunidades alfa de la Proteína de Unión al GTP Gi-Go
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Corteza Renal
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Regul Pept
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos