Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies.
J Neuroimmunol
; 199(1-2): 155-9, 2008 Aug 13.
Article
en En
| MEDLINE
| ID: mdl-18586329
ABSTRACT
Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders. Here we have characterized the clinical and laboratory features of two patients presenting with subacute onset, and chronic evolution, of anterograde amnesia and drug-resistant epilepsy associated with thyroid autoimmunity and in absence of tumoral pathology despite long follow-up. Antibodies against onconeural antigens, voltage gated potassium channel and glutamate receptors, which may accompany paraneoplastic as well as non-paraneoplastic LE, were negative. However, biochemical studies showed high titers, and sustained intrathecal synthesis, of antibodies directed against neuronal glutamic acid decarboxylase (GAD). In one patient, plasma exchange determined a dramatic improvement of the neurological deficits along with the decrease of autoantibodies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Autoantígenos
/
Encéfalo
/
Encefalitis Límbica
/
Glutamato Descarboxilasa
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia