The effect of bisbenzylisoquinoline alkaloids on Trypanosoma cruzi infections in mice.
Int J Antimicrob Agents
; 8(3): 163-70, 1997.
Article
en En
| MEDLINE
| ID: mdl-18611797
ABSTRACT
Five bisbenzylisoquinoline (BBI) alkaloids, curine, cycleanine, isotetandrine, limacine and pheanthine were tested for trypanocidal activity in C 3H He mice infected with Y or CL strain of Trypanosoma cruzi. The activity was compared with the baseline drug, benznidazole. Oral treatment was more effective with curine at 10 mg/kg or with cycleanine at 2 mg/kg daily for 10 days in mice infected with Y or CL strain. In these groups, the parasitemias were negative after 5-7 weeks after inoculation and mortality time 50 (MT(50)) was significantly higher than untreated mice. Benznidazole was effective in mice infected with CL strain but not in mice infected with Y strain. The other BBI showed a relative efficacy against both strains. The effect of BBI alkaloids could be due to a blocking of the Ca2+ channel for the regulation of T. cruzi infectivity to invade host cells or their selective immunosuppressive properties.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Int J Antimicrob Agents
Año:
1997
Tipo del documento:
Article
País de afiliación:
Paraguay