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Electroencephalographic evolution of hypsarrhythmia: toward an early treatment option.
Philippi, Heike; Wohlrab, Gabriele; Bettendorf, Uli; Borusiak, Peter; Kluger, Gerhard; Strobl, Karl; Bast, Thomas.
Afiliación
  • Philippi H; Center of Developmental Neurology and Epileptology, Frankfurt, Germany. hphilippi@vae-ev.de
Epilepsia ; 49(11): 1859-64, 2008 Nov.
Article en En | MEDLINE | ID: mdl-18631366
PURPOSE: A retrospective study for a classification of prehypsarrhythmic elecroencephalographies (EEGs) was carried out to enable an early treatment option for West syndrome. METHODS: Out of 39 infants with symptomatic West syndrome, 18 infants (age 3-14 months) with 61 serial non-REM sleep EEG records of the prehypsarrhythmic phase were identified. The prehypsarrhythmic phase encompassed 2 to 13 months (mean 4.5 months) after an initial insult. A classification system of three EEG types corresponding to the clinical states prior to West syndrome occurrence was developed. In addition, follow-up of all patients presenting with type 2 EEGs (n = 22) was evaluated. RESULTS: Three clinical states and corresponding EEG types were classified. Clinical state 1 (weeks to months, silent phase) presented with (multi-)focal epileptic discharges <50% of the non-REM EEG recording time (type 1 EEG). Clinical state 2 (several weeks, beginning mental deterioration) was accompanied by type 2 EEG with bihemispheric epileptic discharges >50% of the non-REM EEG recording time within abnormal background activity (imminent hypsarrhythmia). Clinical state 3 (mental deterioration) was characterized by hypsarryhthmia. Interrater reliability of seven blinded raters was good (median weighted kappa 0.67). Out of 22 patients presenting with type 2 EEGs, two were lost for follow-up, and 16 developed West syndrome, whereas four were treated early with anti-epileptic drugs and remained stable. CONCLUSIONS: Infants with West syndrome could be reliably identified several weeks before the occurrence of hypsarrhythmia by a typical EEG pattern (type 2), thereby opening the way for early intervention studies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espasmos Infantiles / Electroencefalografía / Anticonvulsivantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Epilepsia Año: 2008 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espasmos Infantiles / Electroencefalografía / Anticonvulsivantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Epilepsia Año: 2008 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos