Zinc-binding compounds induce cancer cell death via distinct modes of action.
Cancer Lett
; 271(2): 251-9, 2008 Nov 28.
Article
en En
| MEDLINE
| ID: mdl-18639975
ABSTRACT
Metal-binding compounds have been shown to have anticancer activity and are being evaluated clinically as anticancer agents. We have recently found that a zinc-binding compound, 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), kills cancer cells by transporting zinc into the cells. We therefore compared the action of clioquinol with two other cytotoxic zinc-binding compounds, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) and pyrrolidine dithiocarbamate (PDTC). We demonstrate that metal-binding compounds can be subclassified based upon the reversibility of their cytotoxicity by metal supplementation and their modes of action. Understanding the mechanisms whereby metal-binding compounds affect cell behavior may aid in their optimization for clinical use.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zinc
/
Apoptosis
/
Clioquinol
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos