Cadherin-7 function in zebrafish development.
Cell Tissue Res
; 334(1): 37-45, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18665394
ABSTRACT
Cadherin cell adhesion molecules play crucial roles in vertebrate development. Most studies have focused on examining the functions of classical type I cadherins (e.g., cadherin-2) in the development of vertebrates. Little information is available concerning the function of classical type II cadherins (e.g., cadherin-7) in vertebrate development. We have previously shown that cadherin-7 mRNA exhibits a dynamic expression pattern in the central nervous system and notochord in embryonic zebrafish. To gain insight into the role of cadherin-7 in the formation of these structures, we analyzed their formation in zebrafish embryos injected with cadherin-7-specific antisense morpholino oligonucleotides (MO). Notochord development was severely disrupted in MO-injected embryos, whereas gross defects in the development of the central nervous system were not detected in MO-injected embryos. Our results thus demonstrate that cadherin-7 plays an important role in the normal development of the zebrafish notochord.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Cadherinas
/
Sistema Nervioso Central
/
Proteínas de Pez Cebra
/
Notocorda
Límite:
Animals
Idioma:
En
Revista:
Cell Tissue Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos