Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.

Nordell, Pär; Westerlund, Fredrik; Reymer, Anna; Nordén, Bengt; Lincoln, Per

Nordell, Pär; Westerlund, Fredrik; Reymer, Anna; Nordén, Bengt; Lincoln, Per.

Afiliación

Nordell P; Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden. par.nordell@chalmers.se

Nucleic Acids Symp Ser (Oxf) ; (52): 131-2, 2008.

Article en En | MEDLINE | ID: mdl-18776288

ABSTRACT

ABSTRACT

High selectivity for long AT sequences can be attained by kinetically controlled DNA threading intercalation by binuclear ruthenium(II) complexes. The rate of intercalation is strongly correlated to the number of consecutive AT basepairs, being up to 2500 times faster with an AT polymer compared to mixed-sequence DNA.

Asunto(s)

ADN/química; Compuestos Organometálicos/química; Poli dA-dT/química; Cinética; Ligandos; Mediciones Luminiscentes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Poli dA-dT / ADN Tipo de estudio: Diagnostic_studies Idioma: En Revista: Nucleic Acids Symp Ser (Oxf) Año: 2008 Tipo del documento: Article País de afiliación: Suecia

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