Dynamics of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides.

Aso, Mariko; Kurita, Manami; Mirc, John Walter; Kaneko, Toshiyuki; Higuchi, Yoshitaka; Koga, Noboru; Suemune, Hiroshi

Aso, Mariko; Kurita, Manami; Mirc, John Walter; Kaneko, Toshiyuki; Higuchi, Yoshitaka; Koga, Noboru; Suemune, Hiroshi.

Afiliación

Aso M; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. aso@phar.kyushu-u.ac.jp

Nucleic Acids Symp Ser (Oxf) ; (52): 151-2, 2008.

Article en En | MEDLINE | ID: mdl-18776298

ABSTRACT

ABSTRACT

We synthesized oligodeoxynucleotide (ODN, 3) containing 2-N-tert-butylaminoxyladenosine (1) and studied EPR spectra of 1 and its duplexes with varied sequences. Duplex formation resulted in a broadening of spectrum and a significant decrease in peak-to-peak height and peak height ratio values. The h(+)/ho values in EPR spectra well correlated with stability of duplex which indicated ODN containing 1 has the potential to monitor DNA structure.

Asunto(s)

Adenosina/análogos & derivados; Oligodesoxirribonucleótidos/química; Marcadores de Spin; Adenosina/química; Espectroscopía de Resonancia por Spin del Electrón

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodesoxirribonucleótidos / Marcadores de Spin / Adenosina Idioma: En Revista: Nucleic Acids Symp Ser (Oxf) Año: 2008 Tipo del documento: Article País de afiliación: Japón

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