Comparative intraperitoneal pharmacokinetics of three platinum analogues.
Cancer Chemother Pharmacol
; 28(4): 315-7, 1991.
Article
en En
| MEDLINE
| ID: mdl-1879050
ABSTRACT
The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organoplatinos
/
Carboplatino
/
Cisplatino
/
Antineoplásicos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido