[Effect of 2,4-dinitrophenol on the rat liver respiratory activity and ATP content after hypothermic storage and following reperfusion].
Ukr Biokhim Zh (1999)
; 80(2): 101-5, 2008.
Article
en Uk
| MEDLINE
| ID: mdl-18819380
ABSTRACT
The influence of oxidative phosphorylation uncoupler 2,4-dinitrophenol (DNP) presence in preserving solution on the rat liver respiratory activity and ATP content after 18 h of hypothermic storage (HS) and following normothermic reperfusion (NR) was investigated. DNP presence on the HS stage led to decrease of ATP level as compared with the control. After DNP removal during NR the gradual recovery of oxidative phosphorylation coupling occurred. This fact resulted in improvement of mitochondrial functional state (V4 respiration rate decrease, respiratory control and ATP level increase).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
/
Reperfusión
/
Adenosina Trifosfato
/
2,4-Dinitrofenol
/
Hipotermia Inducida
/
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Límite:
Animals
Idioma:
Uk
Revista:
Ukr Biokhim Zh (1999)
Año:
2008
Tipo del documento:
Article