In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate.
Int J Pharm
; 365(1-2): 109-15, 2009 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-18822361
The main purpose of this study was to prepare a novel in situ gel system for nasal delivery of MF and study its efficacy on allergic rhinitis model. An ion-activated in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40+/-2 degrees C for 6 months, and the micrographic results showed that in situ gel was safety without mucosa irritation when given at 20 microg once daily for 1 month to rats with allergic rhinitis. MF in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 microg/body following intranasal administration, and the efficacy was significantly superior to that of the common suspension (P<0.01). The in situ gel system is a promising approach for the intranasal delivery of MF for the therapeutic effects improvement.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
/
Pregnadienodioles
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Rinitis Alérgica Perenne
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Antialérgicos
Límite:
Animals
Idioma:
En
Revista:
Int J Pharm
Año:
2009
Tipo del documento:
Article
Pais de publicación:
Países Bajos