Effect of human T lymphotropic retrovirus-I exposure on cultured human glioma cell lines.
Acta Neuropathol
; 81(6): 670-4, 1991.
Article
en En
| MEDLINE
| ID: mdl-1882642
ABSTRACT
Four different human tumor cell lines of glial origin have been exposed to a human T lymphotropic retrovirus (HTLV-I). All these cell lines were positive for the glial marker glial fibrillary acidic protein (GFAP). The presence of virus RNA was demonstrated by in situ hybridization using an HTLV-I, SStI-SStI viral insert as probe. Virus expression has been monitored through an indirect immunofluorescence assay using a monoclonal antibody against virus core protein p19. All the four glioma cell lines tested became positive for p19 after 2 weeks of co-cultivation and showed a clear alteration of GFAP expression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Tumorales Cultivadas
/
Virus Linfotrópico T Tipo 1 Humano
/
Glioma
Límite:
Humans
Idioma:
En
Revista:
Acta Neuropathol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia