Neurological deficits associated with the elastase-induced aneurysm model in rabbits.
Neurol Res
; 31(4): 414-9, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-18826754
ABSTRACT
OBJECTIVE:
Although the rabbit elastase-induced aneurysm model is currently used widely for endovascular research and device testing, procedural causes leading to animal morbidity and mortality have not yet been clearly described. We conducted a retrospective study to analyse factors contributing to neurological deficits in rabbits that underwent the elastase-induced aneurysm creation procedure at our research center from 2002 to 2005 in order to improve the technique and reduce procedure-related morbidity and mortality.METHODS:
A total sample of 38 animals that underwent the procedure under the same conditions was analysed in two groups animals that presented neurological deficits (ND, n=15) and animals that were neurological deficit free (NDF, n=23). Data were collected by reviewing the animal records and radiographic images from the procedures. Statistical analyses using the Mann-Whitney test, unpaired t-test with Welch correction and Fisher's exact tests were performed to compare the two groups based on variables associated with endothelial injury and activation of the coagulation cascade.RESULTS:
The variables of animal weight (signifying state of health of the animal), total procedure time, total balloon occlusion time and clot formation were found to be significantly and/or very significantly correlated to ND presentation.DISCUSSION:
Successful creation of the rabbit elastase-induced aneurysm model depends on careful control over several technical details. Important variables governing outcome have been identified here. A specific, improved endovascular arrangement that facilitates maneuvering of the devices and reduces the risk of air emboli is presented.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Elastasa Pancreática
/
Modelos Animales de Enfermedad
/
Aneurisma
/
Enfermedades del Sistema Nervioso
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Neurol Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos