Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia.
Schizophr Res
; 106(2-3): 248-52, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-18838251
ABSTRACT
Tardive dyskinesia (TD) is a motor adverse effect of chronic antipsychotic medication. It has been suggested to involve dopamine neurotransmission system changes. AKT1 acts downstream of the D(2) receptor that is blocked by all antipsychotics to some degree. The AKT1 gene has not been investigated in TD. We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia sample of 193 Caucasians, 76 of which with TD. AKT1 polymorphisms and haplotypes were not significantly associated with TD. However, we detected a significant interaction between rs6275 of DRD2 and rs3730358 of AKT1 (p<1 x 10(-5)).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
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Esquizofrenia
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Antipsicóticos
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Receptores de Dopamina D2
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Discinesia Inducida por Medicamentos
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Proteínas Proto-Oncogénicas c-akt
Tipo de estudio:
Etiology_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Schizophr Res
Asunto de la revista:
PSIQUIATRIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Canadá