Post-traumatic hypothalamic-pituitary dysfunction presenting with biochemical features of primary hypothyroidism.
Ann Clin Biochem
; 28 ( Pt 4): 327-30, 1991 Jul.
Article
en En
| MEDLINE
| ID: mdl-1892342
ABSTRACT
Two cases of post-traumatic hypothalamic-pituitary dysfunction are described where the primary pathology was shown to be understimulation of the pituitary by hypothalamic hormones. In each case, the biochemical presentation was a low serum thyroxine and elevated TSH concentration mimicking primary hypothyroidism. Treatment with thyroxine before cortisol replacement was not beneficial. In both cases, hydrocortisone therapy alone resulted in a rise in serum thyroxine and fall in serum TSH. Chronic cortisol deficiency may directly impair the thyroid response to TSH, whilst thyroxine appears to exert its feedback primarily at pituitary rather than hypothalamic level.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos Craneocerebrales
/
Sistema Hipotálamo-Hipofisario
/
Hipotiroidismo
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Clin Biochem
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido