Synthesis and molluscicidal activity of some new thiophene, thiadiazole and pyrazole derivatives.
Eur J Med Chem
; 44(3): 1250-6, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-18930566
ABSTRACT
The base-catalyzed reaction of benzoyl acetone 1 with phenyl isothiocyanate yields the non-isolable intermediate 2. Treatment of 2 with dilute HCl afforded the corresponding thiocarbamoyl derivative 3. Reaction of the intermediate 2 with phenacyl bromide, ethyl bromoacetate, chloroacetonitrile, chloroacetyl chloride, bromodiethyl malonate and chloroacetone afforded the corresponding thiophene derivatives 5, 8, 15 and 17. The thiocarbamoyl derivative 3 reacts with arylazophenacyl bromide and/or hydrazine hydrate to afford the corresponding thiadiazole and pyrazole derivatives 20a-c and 22, respectively. These new synthesized compounds show generally a moderate molluscicidal activity to Biomphalaria alexandrina snails.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Tiadiazoles
/
Tiofenos
/
Biomphalaria
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2009
Tipo del documento:
Article
País de afiliación:
Egipto