WAVECLOCK: wavelet analysis of circadian oscillation.
Bioinformatics
; 24(23): 2794-5, 2008 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-18931366
ABSTRACT
UNLABELLED Oscillations in mRNA and protein of circadian clock components can be continuously monitored in vitro using synchronized cell lines. These rhythms can be highly variable due to culture conditions and are non-stationary due to baseline trends, damping and drift in period length. We present a technique for characterizing the modal frequencies of oscillation using continuous wavelet decomposition to non-parametrically model changes in amplitude and period while removing baseline effects and noise. AVAILABILITY:
The method has been implemented as the package waveclock for the free statistical software program R and is available for download from http//cran.r-project.org/
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ritmo Circadiano
/
Biología Computacional
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2008
Tipo del documento:
Article