Construction of an encapsulated ESAT-6-based anti-TB DNA vaccine and evaluation of its immunogenic properties.
Biol Chem
; 389(5): 579-83, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18953725
ABSTRACT
Experimental preparations based on a DNA vaccine encoding the ESAT-6 antigen of Mycobacterium tuberculosis have been obtained (KpONE6) and studied for immunogenic effects in the murine model. The core of the preparation contains DNA of the recombinant plasmid pONE6 encapsulated within a spermidine-polyglucin conjugate, thereby protecting the DNA vaccine from degradation. KpONE6 induces a proliferative T-cell immune response in mice upon intramuscular immunization.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Vacunas contra la Tuberculosis
/
Antígenos Bacterianos
Límite:
Animals
Idioma:
En
Revista:
Biol Chem
Asunto de la revista:
BIOQUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Rusia