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Lacrimal gland radiosensitivity in uveal melanoma patients.
Muller, Karin; Nowak, Peter J C M; Naus, Nicole; de Pan, Connie; van Santen, Cornelis A; Levendag, Peter; Luyten, Gré P M.
Afiliación
  • Muller K; Department of Radiation-Oncology, Erasmus Medical Center, Rotterdam, The Netherlands. k.muller@erasmusmc.nl
Int J Radiat Oncol Biol Phys ; 74(2): 497-502, 2009 Jun 01.
Article en En | MEDLINE | ID: mdl-18963540
PURPOSE: To find a dose-volume effect for inhomogeneous irradiated lacrimal glands. METHODS AND MATERIALS: Between 1999 and 2006, 72 patients (42 men and 30 women) were treated with fractionated stereotactic radiotherapy in a prospective, nonrandomized clinical trial (median follow-up, 32 months). A total dose of 50 Gy was given on 5 consecutive days. The mean of all Schirmer test results obtained > or =6 months after treatment was correlated with the radiation dose delivered to the lacrimal gland. Also, the appearance of dry eye syndrome (DES) was related to the lacrimal gland dose distribution. RESULTS: Of the 72 patients, 17 developed a late Schirmer value <10 mm; 9 patients developed DES. A statistically significant relationship was found between the received median dose in the lacrimal gland vs. reduced tear production (p = 0.000) and vs. the appearance of DES (p = 0.003), respectively. A median dose of 7 Gy/fraction to the lacrimal gland caused a 50% risk of low Schirmer results. A median dose of 10 Gy resulted in a 50% probability of DES. CONCLUSION: We found a clear dose-volume relationship for irradiated lacrimal glands with regard to reduced tear production and the appearance of DES.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Neoplasias de la Úvea / Síndromes de Ojo Seco / Radiocirugia / Aparato Lagrimal / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Neoplasias de la Úvea / Síndromes de Ojo Seco / Radiocirugia / Aparato Lagrimal / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos