Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.
Food Chem Toxicol
; 46(12): 3842-50, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-18976688
ABSTRACT
The chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds was examined on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice. To the best of our knowledge, this is the first report of Fennel seeds exhibiting a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group. Further, biochemical assays showed a significant increase in the content/activities of phase I enzymes especially in the case of 6% test diet. A concomitant increase in the activities of the phase II enzymes were observed with all the doses of test diet under study. A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6% test diets of Fennel. Glyoxalase I activity and the content of reduced glutathione were significantly elevated. Expectedly, the levels of peroxidative damage along with lactate dehydrogenase activity, exhibited a significant reduction at all three doses of test diets. These findings were indicative of chemopreventive potential of Fennel against carcinogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papiloma
/
Neoplasias Cutáneas
/
Neoplasias Gástricas
/
Xenobióticos
/
Anticarcinógenos
/
Foeniculum
/
Antioxidantes
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2008
Tipo del documento:
Article
País de afiliación:
India