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Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds.
Westermann, Cornélie M; Dorland, Bert; de Sain-van der Velden, Monique G; Wijnberg, Inge D; Van Breda, Eric; De Graaf-Roelfsema, Ellen; Keizer, Hans A; Van der Kolk, Johannes H.
Afiliación
  • Westermann CM; Department of Equine Sciences, Medicine Section, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands.
Am J Vet Res ; 69(11): 1469-75, 2008 Nov.
Article en En | MEDLINE | ID: mdl-18980429
OBJECTIVE: To evaluate alterations in skeletal muscle carnitine metabolism during exercise and training by measuring changes in plasma acylcarnitine concentrations in Standardbreds. ANIMALS: 10 Standardbred geldings with a mean +/- SD age of 20 +/- 2 months and weight of 384 +/- 42 kg. PROCEDURES: In a 32-week longitudinal study, training on a treadmill was divided into 4 phases as follows: phase 1, acclimatization for 4 weeks; phase 2, 18 weeks with alternating endurance and high-intensity exercise training; phase 3, increased training volume and intensity for another 6 weeks; and phase 4, deconditioning for 4 weeks. In phase 3, horses were randomly assigned to 2 groups as follows: control horses (which continued training at the same level as in phase 2) and high-intensity exercise trained horses. At the end of each phase, a standardized exercise test (SET) was performed. Plasma acylcarnitine, fatty acids, and lactic acid and serum beta-hydroxybutyric acid (BHBA) concentrations were assessed before and at different time points after each SET. RESULTS: Plasma lactic acid, total nonesterified fatty acids, 3-hydroxyisobutyric acid, and acetylcarnitine (C2-carnitine) concentrations significantly increased during SETs, whereas serum BHBA, plasma propionylcarnitine (C3-carnitine), and plasma butyryl- and isobutyrylcarnitine (C4-carnitine) concentrations decreased significantly, compared with those before SETs. CONCLUSIONS AND CLINICAL RELEVANCE: Our findings indicated that the plasma acylcarnitine profile in horses likely reflects skeletal muscle carnitine metabolism following exercise, thereby providing a possible practical method to investigate potential disorders in carnitine metabolism in horses with myopathy.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Carnitina / Músculo Esquelético / Ácidos Grasos / Caballos Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Am J Vet Res Año: 2008 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Carnitina / Músculo Esquelético / Ácidos Grasos / Caballos Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Am J Vet Res Año: 2008 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos