Potential neural progenitor cells in fetal liver and regenerating liver.
Cytotechnology
; 56(3): 209-17, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-19002859
ABSTRACT
From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-D -lysine/laminin-coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Cytotechnology
Asunto de la revista:
BIOTECNOLOGIA
/
GENETICA
Año:
2008
Tipo del documento:
Article