Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.
Soc Cogn Affect Neurosci
; 3(2): 135-43, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-19015104
ABSTRACT
Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model of the functional cerebral network engaged during explicit emotion processing in adults with high functioning autism or Asperger syndrome. Comparison of structural equation models revealed abnormal patterns of effective connectivity, with the prefrontal cortex as a key site of dysfunction. These findings provide evidence that abnormal long-range connectivity between structures of the 'social brain' could explain the socio-emotional troubles that characterize the autistic pathology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Autístico
/
Percepción Social
/
Corteza Prefrontal
/
Emociones
/
Vías Nerviosas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Soc Cogn Affect Neurosci
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia