Asymmetric divisions, aggresomes and apoptosis.
Trends Cell Biol
; 19(1): 1-7, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-19091567
ABSTRACT
Asymmetric cell division (ACD) is a fundamental process used to generate cell diversity during metazoan development that occurs when a cell divides to generate daughter cells adopting distinct fates. Stem cell divisions, for example, are a type of ACD and provide a source of new cells during development and in adult animals. Some ACDs produce a daughter cell that dies. In many cases, the reason why a cell divides to generate a dying daughter remains elusive. It was shown recently that denatured proteins are segregated asymmetrically during cell division. Here, we review data that provide interesting insights into how apoptosis is regulated during ACD and speculate on potential connections between ACD-induced cell death and partitioning of denatured proteins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
División Celular
/
Apoptosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos